Volume 39, Issue 12

The goals of fMRI acquisition include high spatial and temporal resolutions with a high signal to noise ratio (SNR). Oscillating Steady-State Imaging (OSSI) is a new fMRI acquisition method that provides large oscillating signals with the potential for high SNR, but does so at the expense of spatial and temporal resolutions. The unique oscillation pattern of OSSI images makes it well suited for hi...

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Fully convolutional networks (FCNs) are widely used for instance segmentation. One important challenge is to sufficiently train these networks to yield good generalizations for hard-to-learn pixels, correct prediction of which may greatly affect the success. A typical group of such hard-to-learn pixels are boundaries between instances. Many studies have developed strategies to pay more attention t...

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Medical imaging systems are commonly assessed and optimized by use of objective measures of image quality (IQ). The Ideal Observer (IO) performance has been advocated to provide a figure-of-merit for use in assessing and optimizing imaging systems because the IO sets an upper performance limit among all observers. When joint signal detection and localization tasks are considered, the IO that emplo...

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In this work, we investigate the Fourier properties of a symmetric-geometry computed tomography (SGCT) with linearly distributed source and detector in a stationary configuration. A linkage between the 1D Fourier Transform of a weighted projection from SGCT and the 2D Fourier Transform of a deformed object is established in a simple mathematical form (i.e., the Fourier slice theorem for SGCT). Bas...

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Electrical impedance tomography (EIT) is a non-invasive medical imaging technique in which images of the conductivity in a region of interest in the body are computed from measurements of voltages on electrodes arising from low-frequency, low-amplitude applied currents. Mathematically, the inverse conductivity problem is nonlinear and ill-posed, and the reconstructions have characteristically low ...

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This study evaluates the performance of an acoustic radiation force impulse (ARFI)-based outcome parameter, the decadic logarithm of the variance of acceleration, or log(VoA), for measuring carotid fibrous cap thickness. Carotid plaque fibrous cap thickness measurement by log(VoA) was compared to that by ARFI peak displacement (PD) in patients undergoing clinically indicated carotid endarterectomy...

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Digital Breast Tomosynthesis (DBT) presents out-of-plane artifacts caused by features of high intensity. Given observed data and knowledge about the point spread function (PSF), deconvolution techniques recover data from a blurred version. However, a correct PSF is difficult to achieve and these methods amplify noise. When no information is available about the PSF, blind deconvolution can be used....

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CTP (Computed Tomography Perfusion) is widely used in clinical practice for the evaluation of cerebrovascular disorders. However, CTP involves high radiation dose (≥~200mGy) as the X-ray source remains continuously on during the passage of contrast media. The purpose of this study is to present a low dose CTP technique termed K-space Weighted Image Average (KWIA) using a novel projection view-shar...

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A novel approach of applying deep reinforcement learning to an RF pulse design is introduced. This method, which is referred to as DeepRFSLR, is designed to minimize the peak amplitude or, equivalently, minimize the pulse duration of a multiband refocusing pulse generated by the Shinar Le-Roux (SLR) algorithm. In the method, the root pattern of SLR polynomial, which determines the RF pulse shape, ...

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We present an evolution-strategy based approach to solve the magnitude least squares (MLS) design problem of low flip-angle slice-selective parallel transmit RF pulses for ultra-high field MRI using SAR and peak-RF-constraints. A combined transmit k-space trajectory and RF pulse weight optimization is proposed in two algorithmic steps. The first step is a coarse grid search to find an initial solu...

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Photoacoustic endoscopy (PAE), combining both advantages of optical contrast and acoustic resolution, can visualize the chemical-specific optical information of tissues inside human-body. Recently, its corresponding reconstruction methods have been extensively researched. However, most of them are limited on cylindrical scan trajectories, rather than a helical scan which is more clinically practic...

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